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Typ záznamu * :	článek v odborném periodiku (J)
Domácí pracoviště * :	Katedra interních oborů (11300)
Název * :	Treatment Intensification With Autologous Stem Cell Transplantation and Lenalidomide Maintenance Improves Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma in Complete Response
Citace :	Hájek, R., Mina, R., Petrucci, M., Spada, S., Patriarca, F., Cerrato, C., De Paoli, L., Pescosta, N., Ria, R., Malfitano, A., Musto, P., Baldini, L., Guglielmelli, T., Gamberi, B., Mannina, D., Benevolo, G., Zambello, R., Falcone, A., Palumbo, A. a Nagler, A. et al. Treatment Intensification With Autologous Stem Cell Transplantation and Lenalidomide Maintenance Improves Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma in Complete Response. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2018, 8(18), s. 533-540. ISSN 2152-2650.

Podnázev :
Rok * :	2018
Obor * :
Kód ISSN * :	2152-2650
Oficiální název periodika * :	CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
Stát vydavatele periodika * :	Spojené státy americké
Svazek periodika * :	8
Číslo periodika v rámci svazku * :	18
Číslo článku :
Ročník :
Počet stran článku * :	8
Strana od * :	533
Strana do * :	540
Kód UT WoS :	000439422100009
EID :	2-s2.0-85048391821
Poddruh recenzovaného článku :	Článek v impaktovaném časopise (Jimp)

Klíčová slova anglicky * :	ASCT; CR; Lenalidomide; MM; Treatment intensification
Popis v původním jazyce * :	In patients with a complete response (CR), high-dose therapy with autologous stem cell transplantation (HDT-ASCT) consolidation improved progression-free survival (PFS), second PFS (PFS2), and overall survival (OS) versus R-Alk (lenalidomide, alkylator) consolidation. Also, lenalidomide maintenance therapy enhanced PFS compared with no maintenance therapy. The survival advantage with HDT-ASCT compared with R-Alk in CR patients can be attributed to the greater minimal residual disease negativity rate induced by HDT-ASCT. Background: High-dose therapy with autologous stem cell transplantation (HDT-ASCT) and maintenance treatment with novel agents are the best options for patients with newly diagnosed multiple myeloma, increasing the rate of complete response (CR) and prolonging progression-free survival (PFS) and overall survival (OS). Indeed, the achievement of a CR is a predictor of long-term survival among transplant-eligible patients. However, it is unclear whether patients reaching a CR after induction treatment could receive less intense consolidation or avoid maintenance therapy. Patients and Methods: We analyzed CR patients treated in 2 phase III trials, GIMEMA-RV-MM-PI-209 and RV-MM-EMN-441, to compare HDT-ASCT with an R-Alk (lenalidomide, alkylator) regimen as consolidation, and lenalidomide (R) maintenance with no maintenance. The primary endpoints were PFS, second PFS (PFS2), and OS from consolidation and maintenance (_m). Results: Overall, the data from 166 patients in CR were analyzed, 95 in the HDT-ASCT group and 71 in the R-Alk group. The CR patients who received HDT-ASCT had a better PFS (hazard ratio [HR], 0.55; P = .01), PFS2 (HR, 0.46; P = .02), and OS (HR, 0.42; P = .03) compared with patients randomized to R-Alk. The survival benefit with HDT-ASCT was confirmed among all the subgroups, according to age, International Staging System (ISS stage, cytogenetic profile, and receipt of maintenance therapy. CR patients who received lenalidomide maint
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R01:	RIV/61988987:17110/18:A1901YVL

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