cognitive dysfunction, depressive diso rder, antidepressants, negative bias

kognitivní dysfunkce, depresivní poruch a, antidepresiva, negativní zkreslení

Cognitive dysfunction frequently occurs in acute depression an d can persist into remission. Cognitive impairments impacts on patient functioning and negatively influence ability to perform adequately at work. As evidenced by the results of numerous studies drugs with anticholinergic effect (e. g. tricyclic antide pressants) may adversly affect cognitive functions. The most f re- quently prescribed antidepressants, selective serotonin reuptake inhibitors may improve cognit ivy dysfunction in depression. Agent also including a noradrenergic component such as select ive serotonin and noradrenaline reuptak inhibitorts appears to be more effective in respect to cognitive functions compared to SSRI treatment. Based on the available data, the new multimodal antidepressant vortioxetine may have a specific pro-cognitive effects.