chromosomal aberration; genotoxic risk; occupationalexposure; oncological diseases

The aim of this study is to analyze the genotoxicrisks in the Moravian-Silesian Region in the CzechRepublic and assess the significance of genotoxic factors in the etiology of cancer by bringing together the Registry of Occupational Exposure to Genotoxic Factors and the Cancer Registry and compare the rate of detected cancer in persons exposed to genotoxic factors via their work in the Moravian-Silesian Region with the occurrence of cancer in the population of the Czech Republic.The results show: (a) For the monitored group (748 person) for the period 1996?2008, according to gender, was no statistically significant difference in the incidence of oncological diseases compared to the population of the Czech Republic. (b) But statistically significant difference was found in the cases of oncological diseases in groups according to % AB.C. using the Cytogeneticanalysis of human peripheral lymphocytes (CAPL). Thehighest incidence was in the group with a higher incidence of % AB.C. High values of % AB.C. may predict the development of oncological diseases.