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Publikační činnost

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Typ záznamu:	prezentace (kongresy, sympózia, konference, workshopy)
Domácí pracoviště:	Katedra biologie a ekologie (31700)
Název:	Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera
Citace	Červeň, J., Rybková, Z., Sezimová, H., Pečinka, P. a Malachová, K. Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera. In: The 5th Genetics and Genomics Conference. Nanjing. 2016.

Podnázev
Rok vydání:	2016
Obor:	Genetika a molekulární biologie
Místo konání:	Nanjing
Stát konání akce:
Název akce:	The 5th Genetics and Genomics Conference
Datum od:
Datum do:
Druh prezentace:	Přednáška
Instituce:

Klíčová slova anglicky:	Ames Test, Antimutagenicity, Free Radical Scavenging, DNA Strand Scission, Vitis vinifera
Popis v původním jazyce:	Antimutagenic and DNA protective effect of an extract VinOserae from Vitis vinifera grapes on oxidative DNA damage was investigated. The extract?s ability to inhibit mutagenicity induced by tert-butyl ydroperoxide (t-BHP) and hydrogen peroxide (H2O2)was determined with Ames test using Salmonella typhimurium His TA102 strain. Inhibition values of 44.2 % and 67.0% were d etected for t-BHP and H2O2, respectively. A protective ability of the extract against DNA strand scis-sion induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in plasmid DNA showed a significant inhibition of DNA damage.
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