Metabolism of phenolic compounds (PheCs) is controlled by PAR and its spectral quality. Whereas high irradiance stimulates the PheCs synthesis through unspecific mechanisms such as enhanced ROS production and altered source/sink status of assimilates, spectral quality affects PheCs specifically through activation of photoreceptors. In this work we focused on the role of blue light and its receptors, cryptochromes 1 (CRY1) and 2 (CRY2), in the acclimation from low to high irradiance. Arabidopsis thaliana plants (wild type; WT) and its CRY1CRY2 double mutant were cultivated at low irradiance (LI) of blue (B), greenred (1:1; GR) and white light (W), and then exposed to high irradiance (HI) of the same spectral quality. Our results showed that presence of CRY is not required for HI induced upregulation of PheCs synthesis (at W and GR). However, under B-HI conditions WT plants hyper-accumulate at least six UV-absorbing compounds (most likely PheCs), whereas in CRY mutant the accumulation of PheCs was markedly reduced. Our data indicate that other spectral components of light can be involved in downregulation of B-CRY induced PheCs response to HI (possibly through activation of phytochromes).