delivery, epilepsy, birth length, therapeutic drug monitoring, valproic acid

Maternal and umbilical cord serum levels were analyzed at delivery in a cohort of 58 women, between the years 1991-2013. The request forms for routine therapeutic drug monitoring were used as the data source. Maternal levels and dosing information were used for estimating the maternal apparent oral clearance and the paired umbilical cord and maternal levels for estimation of umbilical cord/maternal level ratios. Result. The levels varied from 5,3-59,5 mg/L in maternal and 5,4-72,1 mg/L in umbilical cord serum. The umbilical cord/maternal level ratios ranged from 0,64-2,49. Significant correlation was found between maternal and umbilical cord levels. Significant inverse correlations were found between birth length, and both maternal and umbilical cord levels in monotherapy.