Intragastric balloon; Leptin; Ghrelin; FGF21; Lipid metabolism; Fat tissue;Weight loss

Introduction: Obesity is associated with a number health-related problems as well as a shortened life span, treating obesity is an important clinical concern. In this study, we examined the effects of the intragastric balloon MedSil? on anthropometric measures and hormones associated with lipid and energy metabolism Methods: Twenty-two obese patients underwent insertion of the intragastric balloon MedSil? following a clinical exam, body composition scan and collection of blood samples. Results: Six months following insertion of the MedSil? balloon, we observed significant decreases in body weight, body mass index, and fat mass. Compared with baseline levels, ghrelin serum levels were increased significantly, while leptin, FGF21 and glycated hemoglobin levels significantly decreased, 6 months after balloon insertion. Conclusion: The MedSil? intragastric balloon is a safe and effective treatment for morbid obesity, with positive effects on anthropometric measures and lipid metabolism.