sleeve gastrectomy, obesity, Ghrelin, Leptin, FABP-4

Metabolic surgery is fully accepted treatment modality in severe obesity nowadays. Some controversies still exsit concerning metabolic changes after different procedures. The authors present results from the pilot study after sleeve gastrectomy. 53 consecutive patiens ( 42 women, 11 men) for sleeve gastrectomy were enrolled into the prospective study. All patiens fulfilled inclusion criteria. Concentration of serum Ghrelin, Leptin, TNF- ? , Adiponectin, Resistin and FABP4 were determined before the operation, three and six month after the operation. For this study results in 16 women with follow up interval 3 month were analysed. Concentration of Ghrelin, Leptin were significantly lower , while concentration of FAB4 were higher. Changes in concentration of Resistin, TNF- ? and Adiponectin has shown no significance. Lower concentration of Ghrelin and Leptin corelate with performed procedures and weight reduction. For increase concentrations of FABP4 the authors have no explanation now.