Acute kidney injury; Hemodialysis; High-flux; Low-flux; Polysulphone membrane; Sepsis; Vancomycin

To determine the extent of vancomycin removal and vancomycin pharmacokinetics in septic patients with AKI using daily hemodialysis with polysulphone high-flux and low-flux membrane. Methods. Five patients received 6 h daily dialysis with low-flux polysulphone membrane, four patients with highflux polysulphone membrane. Vancomycin was administered over the last hour of dialysis. The maintenance dose was adjusted based on pre-hemodialysis serum concentrations. Patients were followed up for two days. Median percentage of vancomycin removal by low-flux membrane dialysis was 17% (8 - 38%) and by highflux membrane dialysis was 31% (13-43%).

Aims. To determine the extent of vancomycin removal and vancomycin pharmacokinetics in septic patients with AKI using daily hemodialysis with polysulphone high-flux and low-flux membrane. Methods. Five patients received 6 h daily dialysis with low-flux polysulphone membrane, four patients with highflux polysulphone membrane. Vancomycin was administered over the last hour of dialysis. The maintenance dose was adjusted based on pre-hemodialysis serum concentrations. Patients were followed up for two days. Results. Median percentage of vancomycin removal by low-flux membrane dialysis was 17% (8 - 38%) and by highflux membrane dialysis was 31% (13-43%). Vancomycin.....