SPECT; parkinsonian syndromes; essential tremor; psychogenic movement disorder

Diagnosis of Parkinson's disease (PD) could be difficult in early stages of the disease. Transcranial sonography (TCS) is able to detect structural changes in substantia nigra in PD patients. FP-CIT SPECT imaging could detect presynaptic dysfunction in several neurodegenerative disease. Methods: We examined 25 patients (19 male, mean age 57.2?8.4 years) during 2 years - 4 patients with ET, 12 PD patients, 7 PS patients, and 2 PMD patients. SN echogenicity and SN area were detected using TCS and SPECT evaluation of basal ganglia were performed using SPECT with DAT-ligand (123I-ioflupan) within 2 months after clinical examination. The sensitivity, specificity, positive predictive (PPV) and negative predictive (NPV) values for TCS and SPECT were evaluated.