ischemic stroke; intravenous thrombolysis; magnetic resonance imaging Key Words Plus: ACUTE ISCHEMIC-STROKE; TISSUE-PLASMINOGEN ACTIVATOR; PERFUSION-WEIGHTED MRI; HYPERACUTE STROKE; CONTROLLED-TRIALS; COLLATERAL FLOW; PENUMBRA; THERAPY; THRESHOLDS; PARAMETERS

Background and purpose: Mismatch between stroke severity, assessed by the National Institutes of Health Stroke Scale (NIHSS), and the infarction volume on MRI-DWI (Clinical-Diffusion Mismatch; CDM) may predict follow-up infarction expansion and early neurological deterioration. The aim was to compare infarction growth, clinical outcomes and incidence of symptomatic intracerebral hemorrhage (sICH) in acute ischemic stroke (IS) patients presented with and without CDM treated with intravenous thrombolysis (IVT) within three hours. Patients and methods: The set of 125 consecutive hemispheric IS patients (78 males, mean age 66.0 +/- 12.1 years) were retrospectively analyzed. CDM was defined as NIHSS >= 8 and DWI volume <= 25 ml, non-mismatch as NIHSS >= 8 and DWI volume > 25 ml. Infarction volume was measured on admission and after 24 hours. Neurological deficit ....etc.