Alfa-blockers; Anticholinergics; Lower urinary tract symptoms; Overactive bladder

Symptomy hyperaktivního měchýře trpí asi 16 % dospělé populace v Evropě. Nejčastější a nejúčinnější léčbou je farmakoterapie anticholinergiky. V poslední době je podána řada důkazů in-vitro o vlivu alfalytik na detruzor.

Overactive bladder (OAB) is one of the most common medical conditions with an estimated 16 percent of adult population being affected in Europe. The administration of anticholinergics is considered as the most frequent and most effective treatment. There is a evidence that alpha-blockers affect a detrusor function. The aim of the study is to investigate if the combinant therapy consisting of anticholinergics plus alpha-blockers could be beneficial for women suffering from OAB. Our results can not show explicitly higher efficacy of combination treatment using anticholinergics plus alpha-blockers comparing to standard therapy by anticholinergics alone. Further randomised placebo-controlled studies are needed for final evaluation of the role of alpha-blockers in the treatment of OAB.