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Publikační činnost

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Typ záznamu * :	článek v odborném periodiku (J)
Domácí pracoviště * :	Katedra biologie a ekologie (31700)
Název * :	Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects
Citace :	Bláha, L., Hilscherová, K., Mazurová, E., Hecker, M., Jones, P. D., Newsted, J. L., Bradley, P. W., Gracia, T., Ďuriš, Z., Horká, I., Holoubek, I. a Giesy, J. P. Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects. Environment International. 2006, roč. 32, č. 3, s. 749-757. ISSN 0160-4120.

Podnázev :
Rok * :	2006
Obor * :	Vliv životního prostředí na zdraví
Kód ISSN * :	0160-4120
Oficiální název periodika * :	Environment International
Stát vydavatele periodika * :	Spojené státy americké
Svazek periodika * :	3
Číslo periodika v rámci svazku * :	1
Číslo článku :
Ročník :	32
Počet stran článku * :	9
Strana od * :	749
Strana do * :	757
Kód UT WoS :	000239095700007
EID :
Poddruh recenzovaného článku :	Článek v impaktovaném časopise (Jimp)

Klíčová slova anglicky * :	Estrogen receptor; ER; Arylhydrocarbon receptor; AhR; Dioxin; Coal sediment; Crayfish; Astacus leptodactylus; Intersex; Steroidogenesis; H295R
Popis v původním jazyce * :	A novel bioassay with the human adrenocortical carcinoma cell line H295R can be used to screen for endocrine disrupting chemicals that affect the expression of genes important in steroidogenesis. This assay was employed to study the effects of organic contaminants associated with the freshwater pond sediments collected in the Ostrava-Karvina region, Czech Republic. Crude sediment extracts, containing high concentrations of polycyclic aromatic hydrocarbons (PAHs) and moderate amounts of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) significantly stimulated expression of the CYP11B2 gene (up to 10-fold induction), and suppressed expression of 3?HSD2 and CYP21 genes. Pronounced effects were observed particularly in sediment extracts from the Pilnok Pond which harbors an unusual intersexual population of the narrow-cawed crayfish Pontastacus leptodactylus.
Popis v anglickém jazyce * :	A novel bioassay with the human adrenocortical carcinoma cell line H295R can be used to screen for endocrine disrupting chemicals that affect the expression of genes important in steroidogenesis. This assay was employed to study the effects of organic contaminants associated with the freshwater pond sediments collected in the Ostrava-Karvina region, Czech Republic. Crude sediment extracts, containing high concentrations of polycyclic aromatic hydrocarbons (PAHs) and moderate amounts of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) significantly stimulated expression of the CYP11B2 gene (up to 10-fold induction), and suppressed expression of 3?HSD2 and CYP21 genes. Pronounced effects were observed particularly in sediment extracts from the Pilnok Pond which harbors an unusual intersexual population of the narrow-cawed crayfish Pontastacus leptodactylus.

Typ zdroje financování výsledku * :

Projekty CEP/Záměry CEZ

Seznam projektů :

ID Projektu	Název projektu

Seznam ohlasů :

Ohlas

R01:	RIV/61988987:17310/06:A0800HBO

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