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Typ záznamu:
stať ve sborníku (D)
Domácí pracoviště:
Ústav fyziologie a patofyziologie (11501)
Název:
Effect of a new laparoscopic partial jejuno-ileal diversion on bile acid levels and progression of type 2 diabetes mellitus
Citace
Reznickova, K., Svoboda, P., Modos, I., Hubackova, S. S., Vecka, M., Kasperova, B. J., Pleyerova, I., Havrlantova, T., Pavlovicova, R., Cechova, M., Lacinova, Z., Klouckova, J., Machackova, J., Holeczy, P., Bužga, M. a Haluzik, M. Effect of a new laparoscopic partial jejuno-ileal diversion on bile acid levels and progression of type 2 diabetes mellitus.
In:
57TH ANNUAL SCIENTIFIC MEETING: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION: Special Issue:57TH ANNUAL SCIENTIFIC MEETING – 7–9 June 2023, Prague, Czech Republic 2023-06-07 Praha.
Hoboken: Wiley, 2023. s. 51-51. ISSN 0014-2972.
Podnázev
Rok vydání:
2023
Obor:
Počet stran:
1
Strana od:
51
Strana do:
51
Forma vydání:
Elektronická verze
Kód ISBN:
neuvedeno
Kód ISSN:
0014-2972
Název sborníku:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION: Special Issue:57TH ANNUAL SCIENTIFIC MEETING – 7–9 June 2023, Prague, Czech Republic
Sborník:
Mezinárodní
Název nakladatele:
Wiley
Místo vydání:
Hoboken
Stát vydání:
Sborník vydaný v zahraničí
Název konference:
57TH ANNUAL SCIENTIFIC MEETING
Místo konání konference:
Praha
Datum zahájení konference:
Typ akce podle státní
příslušnosti účastníků akce:
Celosvětová akce
Kód UT WoS:
001043106300095
EID:
Klíčová slova anglicky:
partial jejuno-ileal diversion;type 2 diabetes mellitus;obesity
Popis v původním jazyce:
Obesity and type 2 diabetes mellitus (T2DM) are one of the most prevalent chronic diseases. New types of bariatric interventions, such as partial jejuno-ileal diversion (PJID), are becoming popular for reduction of obesity. Bile acids play an important role in lipid absorption, however can serve as signalling molecules that modulate glucose metabolism. Our study was designed to investigate the effect of PJID on the alteration of bile acid levels in patients with obesity and T2DM. Surgery was performed in 15 patients (5 males/10 females; age 47.6 ± 7.9 years; weight 117 ± 21 kg; BMI 42.1 ± 5.5 kg/m2; 9 non-T2DM/6 T2DM) who were followed up for 24 months. Meal test was used to determine postprandial bile acid levels, which were detected by liquid chromatography with mass spectrometry, and assessment was based on area under the curve. After PJID, weight loss was observed in all patients, and decrease in fasting glycaemia and glycated haemoglobin was also observed in patients with T2DM. Increase in serum levels of free bile acids and decrease levels of tau- and glycol-conjugated bile acids was observed in all patients, with the main change observed for chenodeoxycholic acid. In non-T2DM patients, there was increase in the levels of primary and free bile acids, with the main change observed for cholic acid. Reduced levels of glyco- and tau-conjugated ursodeoxycholic acid were found in T2DM patients. In all cases, this effect remained even 24 months after the surgery. PJID appears to be effective in improving glycemic control and in weight reduction. The results of the study also suggest an effect of PJID on the spectrum of bile acids, which may contribute to the overall improvement of metabolic parameters of patients. Thus, bile acids may represent a potential target in the treatment of T2DM.
Popis v anglickém jazyce:
Seznam ohlasů
Ohlas
R01:
RIV/61988987:17110/23:A2502NY2
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