cryptogenic cirrhosis; obesity; risk-factors

Nonalcoholic fatty liver disease (NAFLD) is a predominant etiologic factor for liver disease. The risk of the development of hepatocellular carcinoma (HCC) in cases suffering from NAFLD has been stated1. Nonalcoholic teatohepatitis (NASH), a subtype of NAFLD, is a well-known etiologic factor for cirrhosis and it is one of the risk factors for the development of HCC2. In addition, the association of obesity with NAFLD is well established and augmentation in obesity has been associated with an increase in the incidence of HCC1,3. In the present review, the interrelation of NAFLD and HCC, obesity and NAFLD, and obesity and HCC has been purposed to be discussed by taking into consideration the relevant prevalence, clinical evidence, pathogenic mechanisms, and diagnostic parameters.