This paper deals with the geopolitical macro-regionalization and critical geopolitics of the term "Indo-Pacific". The use of this macrotoponym in the last few years demonstrates the geopolitical connotations based on realism, constructivism and institutionalism in the Western discourse to address the new political-economic realities in the region that should properly be called Asia, Indo-Pacific. There is no doubt that the Indo-Pacific is the most complex mega-region that is heterogeneous politically, culturally and economically. But the use of the term "Indo-Pacific" brings confusion, different states deal with the concept differently, the general perception is complicated by cultural and political differences, the concept brings the possible issue of global security. What can be done for its use, sustainable engagement and perception in the international community against hybrid securitization and exclusionism?