Neurology, Quality of life, Validity, Reliability, Questionnaire

The objective of this study was the development and psychometric evaluation of the quality of life questionnaire for patients with progressive neurological diseases in the advanced stage of the disease. The study comprised 333 patients with severe progressive neurological disease (mean age: 65.4; 56% females). The development questionnaire was tested: convergent validity (confirmatory factor analysis), reliability (Cronbach alpha), test-retest reliability, correlation analysis, construct validity (Spearman coefficient). Acceptable reliability was found in all domains of the PNDQoL questionnaire (alpha = 0.727-0.834), test-retest reliability (r = 0.721-0.980; p < 0,001). The PNDQoL questionnaire is a valid and is suitable for patients in advanced stages of the disease. It may be used to analyze the impact of the disease and its treatment on patients ' life.