Publ3 search

Error:

Javascript is disabled in this browser. This page requires Javascript. Modify your browser's settings to allow Javascript to execute. See your browser's documentation for specific instructions.

Publikační činnost

Probíhá načítání, čekejte prosím...

Typ záznamu * :	článek v odborném periodiku (J)
Domácí pracoviště * :	Katedra biologie a ekologie (31700)
Název * :	Global analysis of inverted repeat sequences in human gene promoters reveals their non-random distribution and association with speci fic biological pathways
Citace :	Brázda, V., Bartas, M., Lýsek, J., Coufal, J. a Fojta, M. Global analysis of inverted repeat sequences in human gene promoters reveals their non-random distribution and association with speci fic biological pathways. Genomics. 2020, 112(4), s. 2772-2777. ISSN 0888-7543.

Podnázev :
Rok * :	2020
Obor * :
Kód ISSN * :	0888-7543
Oficiální název periodika * :	Genomics
Stát vydavatele periodika * :	Spojené státy americké
Svazek periodika * :	112
Číslo periodika v rámci svazku * :	4
Číslo článku :
Ročník :
Počet stran článku * :	6
Strana od * :	2772
Strana do * :	2777
Kód UT WoS :	000534479700011
EID :
Poddruh recenzovaného článku :	Článek v impaktovaném časopise (Jimp)

Klíčová slova anglicky * :	Inverted repeat; Promoter; Human; Genome; Distribution
Popis v původním jazyce * :	Inverted repeats (IR) play important roles in specific DNA-dependent processes in simple prokaryotes to complex eukaryotes. They are recognized by a variety of proteins including restriction enzymes, helicases and transcription factors. We evaluate the presence and localization of IRs in all validated human promoter sequences within 1000 bp upstream and downstream of the transcription start site (TSS). The occurrence of 7 bp and longer IRs is located non-randomly in promoter regions, with enrichment within 200 bp upstream of the TSS. The highest frequency of IRs is just before TSS for repeats of 8 bp or longer. A comparison of promoters divided according to the occurrence of five individual promoter motifs shows unique location patterns of IRs. Principal component analyses and hierarchical clustering of IRs abundance demonstrated that they are depleted and/or not enriched in the promoters of stably expressed genes, but show significant enrichments for specific dynamically regulated biological pathways.
Popis v anglickém jazyce * :	Inverted repeats (IR) play important roles in specific DNA-dependent processes in simple prokaryotes to complex eukaryotes. They are recognized by a variety of proteins including restriction enzymes, helicases and transcription factors. We evaluate the presence and localization of IRs in all validated human promoter sequences within 1000 bp upstream and downstream of the transcription start site (TSS). The occurrence of 7 bp and longer IRs is located non-randomly in promoter regions, with enrichment within 200 bp upstream of the TSS. The highest frequency of IRs is just before TSS for repeats of 8 bp or longer. A comparison of promoters divided according to the occurrence of five individual promoter motifs shows unique location patterns of IRs. Principal component analyses and hierarchical clustering of IRs abundance demonstrated that they are depleted and/or not enriched in the promoters of stably expressed genes, but show significant enrichments for specific dynamically regulated biological pathways.

Typ zdroje financování výsledku * :

Institucionální podpora na rozvoj výzkumné organizace

Seznam projektů :

ID Projektu	Název projektu

Seznam ohlasů :

Ohlas

R01:	RIV/61988987:17310/20:A21027WP

Complementary Content

${loading}