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Publikační činnost

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Typ záznamu * :	článek v odborném periodiku (J)
Domácí pracoviště * :	Katedra biologie a ekologie (31700)
Název * :	The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice
Citace :	Dobenecker, M., Marcello, J., Becker, A., Rudensky, E., Bhanu, N. V., Carrol, T., Garcia, B. A., Prinjha, R., Tarakhovsky, A. a Yurchenko, V. The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice. FEBS LETTERS. 2020, 594(20), s. 3324-3337. ISSN 0014-5793.

Podnázev :
Rok * :	2020
Obor * :
Kód ISSN * :	0014-5793
Oficiální název periodika * :	FEBS LETTERS
Stát vydavatele periodika * :	Spojené království Velké Británie a Severního Irska
Svazek periodika * :	594
Číslo periodika v rámci svazku * :	20
Číslo článku :
Ročník :
Počet stran článku * :	14
Strana od * :	3324
Strana do * :	3337
Kód UT WoS :	000564214800001
EID :
Poddruh recenzovaného článku :	Článek v impaktovaném časopise (Jimp)

Klíčová slova anglicky * :	B1 cells; histone methylation; MMSET; NSD2
Popis v původním jazyce * :	Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental antigens, B1 cells regulate the production of polyreactive and low-affinity antibodies for innate humoral immunity. The molecular mechanism of B-cell specification into different subsets is understudied. In this study, we identified lysine methyltransferase NSD2 (MMSET/WHSC1) as a critical regulator of B1 cell development. In contrast to its minor impact on B2 cells, deletion of the catalytic domain of NSD2 in primary B cells impairs the generation of B1 lineage. Thus, NSD2, a histone H3 K36 dimethylase, is the first-in-class epigenetic regulator of a B-cell lineage in mice.
Popis v anglickém jazyce * :	Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental antigens, B1 cells regulate the production of polyreactive and low-affinity antibodies for innate humoral immunity. The molecular mechanism of B-cell specification into different subsets is understudied. In this study, we identified lysine methyltransferase NSD2 (MMSET/WHSC1) as a critical regulator of B1 cell development. In contrast to its minor impact on B2 cells, deletion of the catalytic domain of NSD2 in primary B cells impairs the generation of B1 lineage. Thus, NSD2, a histone H3 K36 dimethylase, is the first-in-class epigenetic regulator of a B-cell lineage in mice.

Typ zdroje financování výsledku * :

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R01:	RIV/61988987:17310/20:A21026IV

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