Clinical, Diagnostic study, adult study,Non oncology study, Endocrinology, benign I, Conventional & Specialised Nuclear Medicine

Minimally invasive radioguided surgery (MIRS) is up-to-date curative approach for patients with primary hyperparathyroidism (PHPT). The conventional dual-phase 99mTc-sestamibi (MIBI) scintigraphy is based on the different thyroid-parathyroid washout and MIRS is generally the most successful within a recommended narrow time window 120-180 min. after preoperative MIBI administration. However, parathyroid adenoma and thyroid gland tracer uptake and washout may vary from patient to patient and these factors may have an effect on the MIRS success rate.For this reason we perform "Multiple-phase scintigraphy" to determinate the patient-specific time between preoperative MIBI administration and gamma probe-guided surgery to improve operative success in parathyroid adenoma detection.